50 wins & 78 nominations
- 1997 Nominee American Comedy Award
- Funniest Supporting Actress in a Motion Picture
- 1994 Nominee American Comedy Award
- Funniest Actress in a Motion Picture (Leading Role)
- 1992 Winner American Comedy Award
- Funniest Actress in a Motion Picture (Leading Role)
- 2007 Nominee Critics Choice Award
- Best Acting Ensemble
Shared with: Lindsay Lohan · Meryl Streep · Virginia Madsen · Tommy Lee Jones · Maya Rudolph · Kevin Kline · Garrison Keillor · Woody Harrelson · John C. Reilly
- 1994 Nominee CableACE
- Performance in a Comedy Special
- 2016 Nominee Golden Globe
- Best Performance by an Actress in a Television Series - Comedy or Musical
- 2016 Nominee Golden Globe
- Best Performance by an Actress in a Motion Picture - Comedy or Musical
- 1994 Winner Special AwardFor the ensemble cast.Shared with: Andie MacDowell · Bruce Davison · Jack Lemmon · Zane Cassidy · Julianne Moore · Matthew Modine · Anne Archer · Fred Ward · Jennifer Jason Leigh · Chris Penn · Joseph C. Hopkins · Josette Maccario · Lili Taylor · Robert Downey Jr. · Madeleine Stowe · Tim Robbins · Cassie Friel · Dustin Friel · Austin Friel · Tom Waits · Frances McDormand · Peter Gallagher · Jarrett Lennon · Annie Ross · Lori Singer · Lyle Lovett · Buck Henry · Huey Lewis · Danny Darst · Margery Bond · Robert DoQui · Darnell Williams · Michael Beach · Andi Chapman · Deborah Falconer · Susie Cusack · Charles Rocket · Jane Alden
- 1985 Nominee Golden Globe
- Best Performance by an Actress in a Motion Picture - Comedy or Musical
- 2006 Nominee Gotham Independent Film Award
- Best Ensemble Performance
Shared with: Woody Harrelson · Tommy Lee Jones · Garrison Keillor · Kevin Kline · Lindsay Lohan · Virginia Madsen · John C. Reilly · Maya Rudolph · Meryl Streep · L.Q. Jones · Sue Scott · Tim Russell
- 2023 Winner Peabody Award
- Career Achievement Award
- 1976 Nominee Gold Medal
- Favorite Female Star
- 1975 Nominee Gold Medal
- Variety Star
- 2005 Nominee Actor
- Outstanding Performance by an Ensemble in a Drama Series
Shared with: Stockard Channing · Kristin Chenoweth · Dulé Hill · Allison Janney · Joshua Malina · Mary McCormack · Janel Moloney · Richard Schiff · Martin Sheen · John Spencer · Bradley Whitford
- 1993 Winner Special Volpi CupShared with: Andie MacDowell · Bruce Davison · Jack Lemmon · Zane Cassidy · Julianne Moore · Matthew Modine · Anne Archer · Fred Ward · Jennifer Jason Leigh · Chris Penn · Joseph C. Hopkins · Josette Maccario · Lili Taylor · Robert Downey Jr. · Madeleine Stowe · Tim Robbins · Cassie Friel · Dustin Friel · Austin Friel · Tom Waits · Frances McDormand · Peter Gallagher · Jarrett Lennon · Annie Ross · Lori Singer · Lyle Lovett · Buck Henry · Huey Lewis · Danny Darst
- 1974 Nominee WGA Award (TV)
- Best Written Variety Script
Shared with: Bob Illes · Rosalyn Drexler · Lorne Michaels · Richard Pryor · Jim Rusk · Herbert Sargent · James R. Stein · Jane Wagner · George Yanok · Ann Elder · Karyl Miller · Rod Warren
- 2015 Nominee DFCC
- Best Actress
Tied with Charlize Theron for Mad Max: Fury Road (2015) and Emily Blunt for Sicario (2015) in 4th place
- 2019 Winner CinEuphoria
- Career - Honorary Award
- 2017 Winner Voice Arts Award
- Life Time Achievement Icon Award
- 2007 Nominee Gold Derby Film Award
- Ensemble Cast
Shared with: Woody Harrelson · L.Q. Jones · Tommy Lee Jones · Garrison Keillor · Kevin Kline · Lindsay Lohan · Virginia Madsen · John C. Reilly · Maya Rudolph · Meryl Streep
- 2020 Winner Queerty
- Woof Worthy Influencer
- 2003 Winner Mark Twain Prize
- Mark Twain Prize for American Humor
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