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- Using a crack team of doctors and his wits, an antisocial maverick doctor specializing in diagnostic medicine does whatever it takes to solve puzzling cases that come his way.
- Chief of experimental medicine at prestigious hospital uses unorthodox healing methods on critically ill patients. Skilled healer mentors young doctors while treating patients.
- In the near future, a law firm handles difficult cases that reflect the time.
- Del Canyon reluctantly returns to his small hometown to run his family's apothecary, the only source for medical attention for hundreds of miles. The series will follow his emergence as the town healer while he grapples between his desire to distance himself from a painful past and his inability to turn his back on a community struggling to find its place in contemporary America.
- Marty takes on the case of a woman fighting for possession of her dead husband's computerized likeness. Lee May and Darwin find themselves defending a son whose mother is sabotaging his dating life in order not to lose him.
- The firm deals with a case where a mentally dysfunctional man is cured by a process that may ultimately kill him. At the same time they deal with a case that may redefine what a family actually is.
- The firm takes on the national baseball league after a drafted player is banned because he has potential advantages over other players. They also have to combat a lawsuit for work place place harassment brought against one of the associates.
- A case comes up in which genetically tailored children are prone to a high incident of homosexuality. And a woman cyber hijacks the personality of her ex boyfriend because she was lonely.
- The firm take on a case where a man is caught smuggling his own cells back into the country to attempt to clone himself for a life saving operation. An 80's Boy band are in a feud after one of them refuses the plastic surgery to make him look young again.
- The firm agree to handle a case where a woman is claiming she was raped even though she acknowledges the rapist was 20 miles away. A child star brings action to attempt to divorce his parents.
- A teenage girl takes her parents to court because of a tracer system they use that follows every move she makes night and day. A man is in trouble over pre wedding plans when a mate finder program continues to send him suggestions about possible dates.
- A cleaning lady Gideon has known for years comes to the hospital with leukemia.
- A man whom Gideon once treated for cancer comes back to the hospital with a fever and a son who has a chip on his shoulder. Meanwhile, Boies is unable to determine what caused a 35-year-old woman to have a stroke.
- The flirtatious daughter of the hospital's psychiatry chief commits suicide - after she leaves a note accusing Cherry of sexual misconduct. Also, Boies grows more anxious as preparations for the Porter malpractice trial heat up.
- A rich woman with a blood disease picks on the staff, including Gideon and Cabranes. In the meantime, the residents set out to fulfill a dying patient's last wish to be mummified.
- Two patients are in desperate need of a liver transplant when a brain-dead accident victim shows up at the hospital, so Brucie must convince her parents to donate her organs. In the meantime,
- Ellenor Frutt is brought to Metropolitan General after collapsing and tells Ben that her baby comes first if anything happens to her.
- Gideon has developed a drug that could revolutionize treatment for melanoma. The drug is given approval for trials and he offers it to one of his patients before learning that trial subjects must be chosen by a lottery.
- Gideon gets severe heartburn and faints in an exam room. His EKG results are "ambiguous," but he refuses to believe there is something wrong with him, even as Cabranes says it could be a heart attack.
- Staffers look for bacteria that are causing infections in patients who have no connection other than the fact that they're sick.
- During the holidays, Gideon attempts to treat an anemic astronomer who disagrees with the hematology chief. Also, Cabranes volunteers to sing for the hospital's "holiday extravaganza", but Stiles doubts his talent.
- A frequent drug-test volunteer to whom Ollie has gotten close is diagnosed with leukemia. He responds to an experimental treatment, only to get arrested for robbery, but the bright side is that he can't be treated in jail.
- A deaf 14-year-old girl asks for a cochlear implant, but her parents, who are also deaf, are against it. A lawyer for the hospital asks Gideon out and a patient Sid pronounced dead turns out to be alive, but in a vegetative state.
- Boies' father comes to the hospital as a visitor, then ends up as a patient after coughing incessantly in front of Sid. In the meantime, Gideon wonders how a teenage hemophiliac has developed a resistance to the clotting factor.
- Gideon is having a bad day. His son Eli has hit another boy in the head with a brick at school and one of Cabranes' patients wants a fetal-cell transplant that Ben is strictly against.
- While coping with his wife's death from cancer, Dr. Ben Gideon deals with an arrogant cancer patient who dares him to cure him.
- Gideon has developed a drug that could revolutionize treatment for melanoma. The drug is given approval for trials and he offers it to one of his patients before learning that trial subjects must be chosen by a lottery.
- A man comes to the hospital on a Saturday morning, gets treated by six residents and dies on a Sunday night. His case his examined on a Monday morning at an "m and m" conference, and has a profound impact on those involved.
- Cabranes has a psychiatric session with a multiple-personality disorder patient who threatens the hospital with a gun.
- The mayor of Boston, a patient of Gideon's, is diagnosed with cancer, so he has to consider his treatment options before his planned race for the Senate, as well as treatments that could have an effect on his sex life.
- Gideon tries to help a breast-cancer patient who doesn't trust Western medicine. Meanwhile, Ollie attempts to treat a middle-aged man who has daily headaches from his job and Cooper has a patient with a rather embarrassing condition.
- House treats a patient on death row while Dr. Cameron avoids telling a patient she has a terminal illness.
- While House and his team scramble to discover what's causing brain and kidney dysfunction in a pregnant woman, Vogler is on the warpath to get House fired.
- The team takes care of a student with inexplicable electrical shocks, and House's parents visit.
- A nun suffering from acute dermatitis and asthma treated by House with possibly the wrong medication comes dangerously close to death.
- When a famous writer is brought in with language difficulties, House must assist via phone while waiting for a delayed plane.
- A woman comes down with symptoms of African sleeping sickness, but there seems to be no way she could have contracted it. House and his aides must ask a few tough questions and make some tough decisions in order to try to save her.
- A patient with 40% body burns and inexplicable cardiac and neurological signs is treated by the team, while House pursues disproving an old enemy's medical study.
- A morbidly obese ten-year-old girl has a heart attack, and her mother insists that House and his team look past her weight to find the diagnosis. Meanwhile, Vogler pressures House to fire a member of his staff. Clinic Patients: Unidentified man with an infected pierced scrotum; overweight woman with a 30-pound tumor on her ovaries who refuses to have it removed, because she worries she will be unattractive.
- Cuddy joins the team after her handyman falls off of her roof and begins to develop bizarre symptoms. Clinic Cases: African American man who objects to "minority meds."