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- CreatorVictor FrescoStarsSean HayesMegan HiltyEcho KellumCenters on Sean, who must figure out how to parent his 14-year-old daughter, who just moved in, while navigating a temperamental new boss at work.
- CreatorKevin BiegelBill LawrenceStarsCourteney CoxChrista MillerBusy PhilippsFollows the escapades and relationships of a group of neighbors living in Gulfhaven, Florida.
- CreatorBonnie TurnerTerry TurnerStarsJohn LithgowJane CurtinKristen JohnstonA group of aliens is sent to Earth, disguised as a human family, to experience and report life on the third planet from the sun.
- StarsShiri ApplebyAlison BeckerMircea MonroeA girl gets romantic advice from herself ten years in the future via text message.
- CreatorEmily HalpernSarah HaskinsStarsMalin AkermanBradley WhitfordMichaela WatkinsA reformed party girl finds herself an insta-family after falling in love with a man with 3 manipulative children and two judgmental ex-wives.
- CreatorClaudia LonowStarsJenna ElfmanJon FosterAshley Jensen37-year-old Billie breaks up with her boss at the newspaper and gets pregnant by 22-year-old Zack, who moves into her apartment. They both have their pals.
- CreatorJeff FranklinStarsBob SagetJohn StamosDave CoulierA widowed sportscaster raises his three daughters with assistance from his rock and roll brother-in-law and madcap best friend.
- CreatorDJ NashStarsJ.K. SimmonsEli BakerAva Deluca-VerleyA typical family in the middle of a divorce: two kids, mom, dad, and guide dog. Oh, and dad's blind.
- CreatorDavid CraneMarta KauffmanStarsJennifer AnistonCourteney CoxLisa KudrowFollows the personal and professional lives of six twenty to thirty year-old friends living in the Manhattan borough of New York City.
- CreatorMatt TarsesStarsJason BiggsSarah ChalkeJudy GreerRevolves around a quartet of single friends in New York City; two are falling in love, and two despise each other--at least initially.
- CreatorDavid KohanMax MutchnickStarsMichael UrieDavid KrumholtzSophia BushTwo lifelong friends, who are both architects, form a business partnership.
- CreatorCarter BaysCraig ThomasStarsJosh RadnorJason SegelCobie SmuldersA father recounts to his children - through a series of flashbacks - the journey he and his four best friends took leading up to him meeting their mother.
- CreatorWhitney CummingsMichael Patrick KingStarsKat DenningsBeth BehrsGarrett MorrisTwo young women waitressing at a greasy spoon diner strike up an unlikely friendship in the hopes of launching a successful business - if only they can raise the cash.
- CreatorLee AronsohnChuck LorreStarsJon CryerAshton KutcherAngus T. JonesA hedonistic jingle writer's free-wheeling life comes to an abrupt halt when his brother and 10-year-old nephew move into his beach-front house.
- CreatorGemma BakerEddie GorodetskyChuck LorreStarsAllison JanneyAnna FarisMimi KennedyA newly sober single mom tries to pull her life together in Napa Valley while dealing with her wayward mother.
- CreatorDavid KohanMax MutchnickStarsEric McCormackDebra MessingMegan MullallyGay lawyer Will and straight interior designer Grace share a New York City apartment. Their best friends are gleeful and proud gay Jack and charismatic, filthy-rich, amoral socialite Karen.
- CreatorChuck LorreBill PradyStarsJohnny GaleckiJim ParsonsKaley CuocoA woman who moves into an apartment across the hall from two brilliant but socially awkward physicists shows them how little they know about life outside of the laboratory.
- CreatorEileen HeislerDeAnn HelineStarsPatricia HeatonNeil FlynnCharlie McDermottThe daily mishaps of a married woman and her semi-dysfunctional family and their attempts to survive life in general in the town of Orson, Indiana.
- CreatorDavid CaspeStarsEliza CoupeElisha CuthbertZachary KnightonThis Chicago-set sitcom follows the intertwined lives of six young urbanites trying to learn the ropes of adulthood. Through breakups and whatever other curve-balls life throws them, the pals stick together.
- CreatorJennie Snyder UrmanStarsMamie GummerJustin HartleyAja Naomi KingA young doctor realizes that working as an intern in a big hospital is very much the same as being in high school.
- CreatorMindy KalingStarsMindy KalingIke BarinholtzEd WeeksA young Ob/Gyn doctor balances her personal and professional life, surrounded by quirky co-workers in a small office.
- CreatorDavid E. KelleyStarsRobin WilliamsSarah Michelle GellarJames WolkOut-of-the-box Simon Roberts runs an ad agency with his Type-A daughter Sydney.
- CreatorDavid CraneMarta KauffmanStarsKirstie AlleyKathy NajimyDan CorteseVeronica Chase is the ultimate romance expert. Unfortunately, her expertise only works on others. After leaving her philandering husband, she must rebuild her life and her image through her company and with the help of her employees.
- CreatorMarco PennetteStarsKirstie AlleyEric PetersenMichael RichardsAfter his adoptive mother dies, a 26-year-old man tries to connect with his biological mother, a Broadway star.
- CreatorFred BarronMarco PennetteDottie Dartland ZicklinStarsLea ThompsonMalcolm GetsAmy PietzCaroline Duffy is a successful cartoonist in Manhattan, whose eclectic friends are sometimes the subjects of her comic strip.
- CreatorClyde PhillipsSteven PetermanGary DontzigStarsBrooke ShieldsJudd NelsonKathy GriffinJack owns a magazine and is Susan's former brother-in-law. After she is left without her fiancé on her wedding day, Jack agrees to take her back to the magazine.
- CreatorLinwood BoomerMichael GloubermanGary MurphyStarsFrankie MunizBryan CranstonJustin BerfieldA gifted young teen tries to survive life with his dimwitted, dysfunctional family.
- CreatorElizabeth MeriwetherStarsZooey DeschanelJake JohnsonMax GreenfieldAfter a bad break-up, Jess, an offbeat young woman, moves into an apartment loft with three single men. Although they find her behavior very unusual, the men support her - most of the time.
- CreatorCarmen FinestraDavid McFadzeanMatt WilliamsStarsTim AllenEarl HindmanTaran Noah SmithThe daily trials and tribulations of Tim "The Tool Man" Taylor, a television show host raising three mischievous boys with help from his loyal co-host, loving wife, and eccentric neighbor.
- CreatorJack BurdittStarsTim AllenNancy TravisHector ElizondoA married father of three tries to maintain his manliness in a world increasingly dominated by women.
- CreatorTom HertzStarsPatrick WarburtonMegyn PriceOliver HudsonTwo couples and their single friend, all at different stages in their relationships, deal with the complications of dating, commitment, and marriage.
- CreatorDavid LittMichael J. WeithornStarsKevin JamesLeah ReminiJerry StillerDeliveryman Doug Heffernan has a good life: He has a pretty wife (Carrie), a big television, and friends with which to watch it. Then Carrie's goofy, annoying father Arthur moves in with them.
- CreatorTracy GambleStarsKatey SagalKaley CuocoAmy DavidsonThe Hennessy clan -- mother Cate, daughters Bridget and Kerry, and son Rory -- look to one another for guidance and support after the death of Paul, the family patriarch. Cate's parents lend a hand.
- CreatorDavid KendallBob YoungStarsMelissa Joan HartJoey LawrenceTaylor SpreitlerAfter a family scandal leaves Mel, a local politician, in charge of her niece and nephew, she hires a man named Joe to become the family's male nanny, or "manny."
- CreatorMark RobertsStarsBilly GardellMelissa McCarthyReno WilsonA couple meets at an Overeaters' Anonymous meeting.
- CreatorSuzanne MartinStarsValerie BertinelliJane LeevesWendie MalickThree middle-aged best friends from Los Angeles are flying to Paris when their plane makes an emergency landing in Cleveland. Realizing that all the norms from Los Angeles don't apply anymore, they decide to celebrate a city that values real women and stay where they're still considered hot.
- CreatorMark ReismanStarsDonald FaisonWayne KnightDavid Alan BascheA group of divorced friends tries to get back to the single life.
- CreatorKari LizerStarsJulia Louis-DreyfusClark GreggHamish LinklaterA divorced mom tries to keep pace with everyone around her.
- CreatorDavid CraneJeffrey KlarikStarsMatt LeBlancStephen ManganTamsin GreigA couple of British TV producers move to Hollywood to export their most popular series, and find it is not what they expected.
- CreatorShana Goldberg-MeehanScott SilveriStarsMatt LeBlancPaulo CostanzoDrea de MatteoIn this spin-off of Friends (1994), Joey Tribbiani moves to Los Angeles to pursue his acting career.
- CreatorDoug EllinStarsKevin ConnollyAdrian GrenierKevin DillonFilm star, Vince Chase, navigates the vapid terrain of Los Angeles with a close circle of friends and his trusty agent.