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- DirectorNelson McCormickStarsHugh LaurieLisa EdelsteinOmar EppsA girl crashes a Porsche after her boyfriend starts coughing up blood and continues to have unexplained bleeds. Clinic Cases: Cuddy gives House a month off clinic duties if he can spend a week off his pain meds.
- DirectorKeith GordonStarsHugh LaurieLisa EdelsteinOmar EppsA detoxed sports star about to make his comeback breaks his arm due to brittle bones. Clinic Cases: Woman with leg pain, man trying to remove his contact lenses, a dentist with various issues, and a hung over teenager - all in 70 seconds.
- DirectorDaniel SackheimStarsHugh LaurieLisa EdelsteinOmar EppsA young boy's fever lasts nearly a week after a Ouija board predicts he will die. Clinic Cases: Chase's case of a man with numb fingers.
- DirectorRandy ZiskStarsHugh LaurieLisa EdelsteinOmar EppsCan House save a high powered female executive from the same problem that has left him in constant pain? A new head of the hospital board could cause problems. Clinic cases: A boy and his mute dad.
- DirectorTim HunterStarsHugh LaurieLisa EdelsteinOmar EppsA Mob informer collapses before trial. Is he faking or is he really in a coma? Clinic Cases: A pair of brothers come in when the youngster gets toys stuck up his nose.
- DirectorFred GerberStarsHugh LaurieLisa EdelsteinOmar EppsA morbidly obese ten-year-old girl has a heart attack, and her mother insists that House and his team look past her weight to find the diagnosis. Meanwhile, Vogler pressures House to fire a member of his staff. Clinic Patients: Unidentified man with an infected pierced scrotum; overweight woman with a 30-pound tumor on her ovaries who refuses to have it removed, because she worries she will be unattractive.
- DirectorPeter O'FallonStarsHugh LaurieLisa EdelsteinOmar EppsAn ambitious and charismatic Black senator campaigning for the presidency falls ill from a mysterious malady, possibly AIDS.
- DirectorBill JohnsonStarsHugh LaurieLisa EdelsteinOmar EppsWhile House and his team scramble to discover what's causing brain and kidney dysfunction in a pregnant woman, Vogler is on the warpath to get House fired.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsDuring a meningitis outbreak which overwhelms the clinic, House is drawn to a single patient: a 12-year-old competitive diver whose symptoms don't quite match everyone else's.
- DirectorBryan SpicerStarsHugh LaurieLisa EdelsteinOmar EppsHouse has to deal with his promised dinner date with Cameron, a mysterious stroke in a clinic patient and a libidinous senior citizen.
- DirectorParis BarclayStarsHugh LaurieLisa EdelsteinOmar EppsHouse's ex Stacy Warner asks him to treat her husband. House takes over a diagnostics class for a day and presents the class with three case studies of leg pain. As House tells his story and the class gradually fills up with listeners, the class learns a lot about how to be better doctors, and Chase, Foreman and Cameron learn some important details of House's past.
- DirectorFrederick King KellerStarsHugh LaurieLisa EdelsteinOmar EppsHouse doses his ex-girlfriend's husband in order to get him into hospital after she begs House to treat him. Is House treating Mark differently in order to get back at Stacy for his leg?
- DirectorDaniel AttiasStarsHugh LaurieLisa EdelsteinOmar EppsHouse treats a patient on death row while Dr. Cameron avoids telling a patient she has a terminal illness.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsA very brave and mature 9-year-old girl has terminal cancer, but that is not what the problem seems to be.
- DirectorDaniel AttiasStarsHugh LaurieLisa EdelsteinOmar EppsCuddy joins the team after her handyman falls off of her roof and begins to develop bizarre symptoms. Clinic Cases: African American man who objects to "minority meds."
- DirectorPeter O'FallonStarsHugh LaurieLisa EdelsteinOmar EppsA doctor campaigns against the epidemic of TB in Africa, possibly at the risk of his own life.
- DirectorGreg YaitanesStarsHugh LaurieLisa EdelsteinOmar EppsThe team takes care of a student with inexplicable electrical shocks, and House's parents visit.
- DirectorFred GerberStarsHugh LaurieLisa EdelsteinOmar EppsStar bicycle racer collapses, and the team must come up with a diagnosis after the patient admits to blood doping. House and Stacy continue sparring with each other. Clinic Case: Flight attendant poisons himself with gum.
- DirectorGloria MuzioStarsHugh LaurieLisa EdelsteinOmar EppsAfter being accused of assaulting a sick man, House is forced to take on his case. However, despite the fact that he has AIDS, it's clearly not what's killing him.
- DirectorDavid SemelStarsHugh LaurieLisa EdelsteinOmar EppsChaos ensues after Chase's negligence leads to the death of a female patient. Now, after an inquiry from the hospital board, and a subpoena from the patient's brother, it's up to Stacey to protect Chase's career, as well as House's.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsA woman collapses at an off-track betting parlor in front of House, and he must battle his new boss to find her diagnosis.
- DirectorJace AlexanderStarsHugh LaurieLisa EdelsteinOmar EppsWhen a famous writer is brought in with language difficulties, House must assist via phone while waiting for a delayed plane.
- DirectorDavid SemelStarsHugh LaurieLisa EdelsteinOmar EppsHouse and the team must determine what is causing an increasingly deceitful patient's muscle flailing. Stacy makes a decision, and Cameron avoids a test.
- DirectorDaniel AttiasStarsHugh LaurieLisa EdelsteinOmar EppsA patient with 40% body burns and inexplicable cardiac and neurological signs is treated by the team, while House pursues disproving an old enemy's medical study.
- DirectorJames HaymanStarsHugh LaurieLisa EdelsteinOmar EppsThe search for the cause of a supermodel's symptoms causes intense feelings among the team, as new facts are revealed. Meanwhile, House experiences increasing pain in his leg.
- DirectorDavid SemelStarsHugh LaurieLisa EdelsteinOmar EppsHouse and the team struggle to diagnose one patient in order to save another. Clinic Case: College student claims he has the hots for heifers.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsHouse must diagnose a man who became sick and experienced difficulty breathing during sex-play but all tests keep returning normal. Wilson experiences close-up what living with House is like. Clinic case: Herpes
- DirectorFélix Enríquez AlcaláStarsHugh LaurieLisa EdelsteinOmar Epps6 months after a teenage girl crushes her chest in a car accident and receives a heart transplant she goes into anaphylactic shock in her clean bedroom after her boyfriend almost kisses her and discovers something on her arm.
- DirectorFred GerberStarsHugh LaurieLisa EdelsteinOmar EppsOn a class field trip, a teacher discovers that her six-year-old student, Ian, is bleeding profusely. Dr. House thinks Ian has the same unknown disease that killed an elderly patient of his years ago.
- DirectorGreg YaitanesStarsHugh LaurieLisa EdelsteinOmar EppsCameron gets mad at Foreman because Foreman steals his idea for an article. The case of the week: a lesbian woman has not slept for ten days despite taking a bottle of sleeping pills.
- DirectorJohn F. ShowalterStarsHugh LaurieLisa EdelsteinOmar EppsHouse takes on a teenage faith healer, Wilson desperately wants into a poker game, and tensions escalate between Cameron and Foreman.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsA police officer in critical condition has bizarre symptoms, and Dr. Foreman finds himself in an unpleasant situation.
- DirectorDaniel SackheimStarsHugh LaurieLisa EdelsteinOmar EppsA dad kisses his wife and baby goodbye before leaving for work, pukes and returns to find his wife with seizure in the bathtub and the baby under water. Foreman is back but changed.
- DirectorDaniel SackheimStarsHugh LaurieLisa EdelsteinOmar EppsHouse is affected by the fact that he thinks he didn't solve the last case while a young boy, who believes aliens tortured him, is brought in.
- DirectorLaura InnesStarsHugh LaurieLisa EdelsteinOmar EppsHouse and his team face a lot of moral dilemmas when a patient wants them to help him end his life.
- DirectorNewton Thomas SigelStarsHugh LaurieLisa EdelsteinOmar EppsA ten-year-old boy begins screaming in pain, but nobody knows why, because he is autistic and cannot explain. House refuses to use his office because it has new carpet.
- DirectorDavid PlattStarsHugh LaurieLisa EdelsteinOmar EppsA husband and wife being treated cause Foreman to ponder the strength of true love, and House abuses one too many patients with potentially devastating repercussions.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsAn obese man in a coma presents treatment challenges, but finding out what's wrong with him may be the most challenging test of all. Elsewhere, Tritter ramps up his vendetta against House.
- DirectorDaniel AttiasStarsHugh LaurieLisa EdelsteinOmar EppsWhen the son of a man in a vegetative state starts going into a coma, the vegetative man is reawakened chemically by House, who hopes to get some clues to the son's problems.
- DirectorDaniel SackheimStarsHugh LaurieLisa EdelsteinOmar EppsA young man collapses at his job, and House makes a game of establishing the diagnosis until things turn critical, and Tritter increases the pressure on Wilson.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsWhile a little girl's life and limbs are in jeopardy, Tritter becomes more manipulative and House suffers withdrawal.
- DirectorTony ToStarsHugh LaurieLisa EdelsteinOmar EppsWilson presents the deal to House and then convinces Cuddy to back him up, meanwhile the team is flummoxed by a patient's condition and various members keep seeking out House for his opinion even though he may not be prepared to assist.
- DirectorDaniel SackheimStarsHugh LaurieLisa EdelsteinOmar EppsHouse checks himself into rehab just before his trial, but a different game entirely may be afoot. Elsewhere, the team attempts to treat a firefighter who can't stop shivering.
- DirectorJuan José CampanellaStarsHugh LaurieLisa EdelsteinOmar EppsStuck with clinic duty, House almost wishes he had the boring patients back after he encounters a young woman with an STD and the need to talk.
- DirectorPeter O'FallonStarsHugh LaurieLisa EdelsteinOmar EppsA young man is stricken during sex with his girlfriend, and House must determine why his organs are suddenly shutting down. Finding the cause is like looking for a needle in a haystack.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsOn Valentine's Day, House meddles in relationships as he works to diagnose a teenager who has a genetic inability to feel pain.
- DirectorKatie JacobsStarsHugh LaurieLisa EdelsteinOmar EppsHouse struggles to find out why a pianist savant is losing his ability to play. Ultimately, a decision must be made as to how much brain is necessary for a normal quality of life.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsA patient whose relative has called in a favor with Cuddy presents with nonspecific minor symptoms that turn life-threatening, but House is distracted by a dream and an inability to urinate.
- DirectorMatt ShakmanStarsHugh LaurieLisa EdelsteinOmar EppsWhen a pregnant woman has a stroke, the team is at a loss after all tests reveal nothing, but when her organs start shutting down Cuddy takes over the case.
- DirectorElodie KeeneStarsHugh LaurieLisa EdelsteinOmar EppsHouse and Cuddy are flying back to the US from an international conference in Singapore. While en route a mysterious disease strikes one passenger and an epidemic unfolds, causing House to diagnose in midair since they have missed the halfway mark by passing the north pole. Back in Princeton, Wilson and House's lackeys have a confusing case of what is ailing a woman who came into the clinic and proceeded to have a seizure.
- DirectorDaniel SackheimStarsHugh LaurieLisa EdelsteinOmar EppsA young girl is ailed with diseases that usually strike people much older than her 6 years of age. But before House can diagnose her, her brother starts exhibiting the same symptoms she was admitted with. During all of this House gives Wilson tickets that a patient had given to him for a play. Ensuing a discussion on why men take women to plays. Wilson decides to take Cuddy and the tug of war with House for her affections begins, although Cuddy insists that she only went with Wilson as a friend.
- DirectorPaul McCraneStarsHugh LaurieLisa EdelsteinOmar EppsThe cause of a woman's TIA stumps the team, and Foreman's family visits.
- DirectorDavid StraitonStarsHugh LaurieLisa EdelsteinOmar EppsWilson is preparing his 14-year-old patient, Nick, for a bone marrow transplant when the donor, Nick's younger brother Matty, suddenly starts sneezing. Since Nick's immune system has been destroyed by the chemotherapy for his cancer, he cannot risk a marrow donation from Matty while Matty is ill. House decides that the fastest way to find out what's wrong with Matty is to make him worse. As the boys get sicker and sicker, House and his team race to cure Matty before both brothers die. Meanwhile, House battles Hector (his newly adopted dog) for supremacy and Foreman can't stop thinking about last week's mistake.
- DirectorMartha MitchellStarsHugh LaurieLisa EdelsteinOmar EppsA college girl suddenly coughs up blood during karate class. Foreman resigns. A vegan couple has problems with floating poop. House secretly drugs Wilson with amphetamine.
- DirectorDaniel SackheimStarsHugh LaurieLisa EdelsteinOmar EppsWhen a teenage chess player assaults his opponent, the team struggles to determine whether the problem is organic or psychological. Clinic Cases: Spotted sunburn.
- DirectorKatie JacobsStarsHugh LaurieLisa EdelsteinOmar EppsA couple risk their lives getting from Cuba to see House, but his preoccupation with staff issues may cost the woman her life.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsHouse is off his game without the team, and Wilson uses an extreme tactic to force him into interviews.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsHouse is forced to choose a new staff... and gathers 40 applicants to start narrowing down the field. Meanwhile, an Air Force pilot wants House to treat her secretly so she doesn't ruin her chances of becoming an astronaut.
- DirectorDavid PlattStarsHugh LaurieLisa EdelsteinOmar EppsDown to 10 candidates for his team, House splits them into 2 groups to diagnose a patient whose short lifespan has been made even shorter. Foreman leads his own team to diagnose a patient at his new workplace.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsA woman seeing her dead mother stumps the recruits, especially once she begins seeing a recent victim.
- DirectorMartha MitchellStarsHugh LaurieLisa EdelsteinOmar EppsHouse cares for a young Katrina victim, the alleged daughter of an old friend of his. He supposes she has hallucinations because of the heart, but it turns out not to be the cause. House discovers a disease that her grandfather had.
- DirectorDavid ShoreStarsHugh LaurieLisa EdelsteinOmar EppsAn old patient of House comes back and seeks revenge upon him in the form of gunshot.
- DirectorDeran SarafianStarsHugh LaurieLisa EdelsteinOmar EppsRichard, a husband and father living with brain cancer, drives his wheelchair into a pool at a family BBQ. Everyone but his son think that it was suicide from the pain but House will stop at nothing to figure out his true ailment.