- Stated in 2009 interview that she had also been diagnosed with mild schizophrenia, attention deficit disorder, Tourette's syndrome and chronic insomnia.
- Stated in a 2002 interview that she suffers from Obsessive Compulsive Syndrome. Her condition became particularly acute in the late 1990s and early 2000s.
- Originally cast in the role of Rain in Husbands and Wives (1992), and footage was shot. Director Woody Allen decided it wasn't working, and replaced her with Juliette Lewis.
- Turned down the lead in Pretty Woman (1990) due to being cast as Cher's daughter Charlotte in Mermaids (1990), a role she ultimately lost to Winona Ryder.
- Was originally set to play the lead in Tank Girl (1995), but dropped out when she refused to shave her head for the part. The role ultimately went to Lori Petty.
- Gave birth to her 1st child at age 44, a daughter named Arrabelle Jupp in October 2014. Child's father is her boyfriend, Christian Jupp.
- Daughter of Roger Lloyd Pack and Sheila Mackie.
- Her mother was an actors agent.
- She went to 8 schools by she was 18 before her parents allowed her to go to the Italia Conti Stage School.
- Her parents tried to dissuade her from a show biz career.
- Is in a relationship with Christian Jupp. They have a daughter together.
- Niece of Christopher Lloyd Pack.
- Granddaughter of Charles Lloyd Pack.
- Half-sister of Spencer Lloyd Pack, Hartley Lloyd Pack and Louis Lloyd Pack.
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