- While modeling as a young woman in Europe, was once asked to posed nude for the late, eccentric, Spanish surrealist painter, Salvador Dalí. She refused.
- Is fluent in Italian, Spanish, French, Arabic, & Japanese.
- While she was a model, she appeared on the covers of Vogue, Elle and Marie Claire.
- Her daughters, Stella Keitel (fathered by ex-boyfriend Harvey Keitel) and Margaux Guerard, played her daughter at different ages in Goodfellas (1990).
- Performed almost all of her own stunts in Medicine Man (1992).
- Was awarded by the American Psychoanalytic Association for her portrayal of Dr. Melfi on The Sopranos (1999).
- Filed for bankruptcy due to legal fees spent on custody battle with Harvey Keitel. (June 1999)
- Those glasses her character Dr. Melfi wears are really hers; she needs either them or her contacts to be able to see clearly.
- Is spokesperson on behalf of Pfizer's anti-depressant Zoloft, having suffered a bout of clinical depression, then having it treated.
- Her father was of Italian descent. Her mother was born in England, and had French ancestry.
- Sister-in-law of actor Aidan Quinn
- Announced she is finally divorcing estranged husband, Edward James Olmos. (January 2002)
- Men have tried the "I need help" pick-up line. She tells them she's busy and to call Dr. Phil.
- Is a practitioner of Shotokan Karate.
- Favorite actresses are Bette Davis and Jodie Foster.
- Raised in Hicksville, New York.
- Was the first choice for the role of "Mona Lisa Vito" in My Cousin Vinny (1992), but she turned down the role.
- Was considered for the role of Catwoman/Selina Kyle in Batman Returns (1992).
- Former Wilhelmina model.
- Received an honorary fellowship from Yale in February 2002.
- Her first marriage, to Frenchman Daniel Guerard, a salon owner and sometimes actor, lasted approximately between 1979-1983, after she became pregnant, although she says it was a very unhappy marriage.
- Released her memoirs, "On the Couch". (June 2006)
- Her oldest daughter is named Margaux (b. April 25, 1979).
- One of the few of the many actors to have been nominated for an Academy Award to have starred in the Sopranos, with Robert Loggia, David Strathairn, and Lauren Becall.
- Aunt of Ava Eileen Quinn and Mia Quinn.
- Bears a resemblance to Debra Winger. She got the role in Radio Flyer (1992), after Winger passed on it.
- Played Paul Guilfoyle's hostage in Hide and Go Thief (1986). Her sister, Elizabeth Bracco, played a hostage in the series' pilot.
- Older sister of Elizabeth Bracco.
- Alumna of Stella Adler Studio of Acting.
- Ex-stepmother of Mico Olmos and Bodie Olmos.
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