- Along with Ted Danson and Rhea Perlman, he is one of only three actors to appear in all 273 episodes of Cheers (1982).
- Uncle of Jason Sudeikis, Kristen Sudeikis and Lindsay Sudeikis.
- Has played Norm Peterson on seven different shows: Cheers (1982), St. Elsewhere (1982), The Tortellis (1987), The Simpsons (1989), Wings (1990), Frasier (1993), and Family Guy (1999).
- Wendt's maternal grandfather was Tom Howard, a photographer for the Washington bureau of P & A Photographs, who took one of the most famous news photos ever: of murderess Ruth Snyder as she was executed at Sing Sing Prison on January 12, 1928. He modified his miniature plate camera with a long shutter release, then smuggled it into the witness room by strapping it onto his left ankle. The photo was on the front page of the next morning's New York Daily News under the headline: DEAD! The camera is at the Smithsonian Institution.
- Along with John Ratzenberger, Richard Belzer and Paul Fusco, he is one of only four actors to play the same character (Hilary Norman 'Norm' Peterson) on six different shows: Cheers (1982), Frasier (1993), Wings (1990), St. Elsewhere (1982), The Tortellis (1987) and The Simpsons (1989). He has appeared in episodes of all six series with John Ratzenberger.
- Playing Edna Turnblad in Hairspray on Broadway (March 2008)
- Played Macaulay Culkin's father in Michael Jackson's video 'Black or White'.
- Attended University of Notre Dame in South Bend, Indiana for two years. An avid Notre Dame football fan, he attends the annual USC-Notre Dame football game between the two intensely rival schools.
- Is an avid Notre Dame football fan. Always attends the Notre Dame-vs.-USC game when held in Pasadena, California, every two years.
- Children: Hilary Wendt (b. 1985), Joe Wendt (b. 1987) and Daniel Wendt (b. 1990) with Bernadette Birkett.
- In a tribute George wrote for the Second City book, he said that when he joined Second City, it wasn't directly through the troupe as a performer. He had studied the shows for a while and befriended an employee whom he asked about joining. She told him to show up after a performance one day in the afternoon, which he subsequently did. The stage area was littered with cigarette butts, when the woman handed him a broom and said "Welcome to the theater, kid."
- Opened in the play, "12 Angry Men" in Dallas, co-starring Richard Thomas. (February 2007)
- He is of German (from his paternal grandfather) and Irish descent.
- Graduate of Rockhurst College (now known as Rockhurst University) in Kansas City, MO.
- Surname pronounced "Went".
- Brother-in-law of Joe Birkett.
- Born on exactly the same date as Margot Kidder (Lois Lane from the "Superman" movies).
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