He was born with one kidney; the kidney failed and he went on dialysis at age 14. He underwent his first kidney transplant at 14 and had a second transplant on December 29, 2015.
His oldest son, Nicholas Lawrence Eisenberg, was born on April 25, 1997. He also has another son named Christopher.
He and his wife eloped; they were planning a big wedding, but it was put on hold to save money. They had been dating for three years before their engagement on November 26, 2016.
Was good friends with Star Trek: Deep Space Nine Co-Star Nana Visitor.