- Children: sons, Michael and William.
- Her early novels were about family situations and modern society's pressures on women. She was praised for their psychological acuity, and has been called "a modern Jane Austen". In the 1970s, she began writing non-fiction books on feminist issues.
- After her family lost their savings in the Depression, she temporarily discontinued her college education. She got a job writing ad copy for department store Abraham & Straus, and processed orders for the Book of the Month Club.
- She began as a best-selling novelist, and became a noted critic and advocate of the women's movement. As a book reviewer, she defended the artistic merits of Nabokov's "Lolita", among other controversial books. As president of the Authors Guild in the 1960s, she addressed lawmakers about copyright protection. She was also a judge for the Pulitzer Prizes and the National Book Awards.
- The Star Trek: Voyager (1995) character, Captain Kathryn Janeway, was named after her.
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