- Before becoming an actor he worked in the narcotics division of the Detroit Police Department.
- A Korean war veteran, Matheson won both a Bronze Star and a Purple Heart for his exceptional heroism during his tour of duty.
- Best known as volatile businessman "Mark Wilson" on Irwin Allen's sci-fi series, Land of the Giants (1968).
- One daughter from his marriage with Deanna Lund: actress Michele Matheson.
- Matheson was also a jazz drummer, often invited to play on stage by his friend, Buddy Rich.
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