- He is the only actor to appear in Superman (1978), Superman II (1980), Superman III (1983), Supergirl (1984) and Superman IV: The Quest for Peace (1987).
- Appeared as "Dave McFly" in Back to the Future Part II (1989), but his part was cut from the final release and left on the cutting room floor. He was in a scene where Marty encounters his drunken brother in front of Biff's Pleasure Paradise in the alternate 1985.
- He played a character named Boris in both the original Freaky Friday (1976) and the remake Freaky Friday (2003). He is the only actor to appear in both films.
- Played Dave McFly in Back to the Future (1985) and Back to the Future Part III (1990). In both films, his screen sister Linda McFly was played by Wendie Jo Sperber. McClure and Sperber both co-starred in I Wanna Hold Your Hand (1978) and Used Cars (1980). All four films (Back to the Future (1985), Back to the Future Part III (1990), I Wanna Hold Your Hand (1978) and Used Cars (1980)) were written by Bob Gale and Robert Zemeckis, and directed by Robert Zemeckis.
- Along with Christopher Reeve, Margot Kidder, and Jackie Cooper, he is one of only four actors to appear in the first four Superman films: Superman (1978), Superman II (1980), Superman III (1983), and Superman IV: The Quest for Peace (1987).
- He appeared in four films directed by Robert Zemeckis: I Wanna Hold Your Hand (1978), Used Cars (1980), Back to the Future (1985) and Back to the Future Part III (1990). Wendie Jo Sperber also appeared in all four films. Although McClure filmed a scene for Back to the Future Part II (1989), it was cut.
- He was 21 years old when he played a high school class president in Coming Home (1978).
- Good friends with actor Tom Wilson.
- He appeared in two films featuring the song "Earth Angel" by The Penguins: Superman III (1983) and Back to the Future (1985).
- Has appeared in more live-action DC movies than any actor to date, seven in total. He played Jimmy Olsen in Superman (1978), Superman II (1980), Superman III (1983), Supergirl (1984) and Superman IV: The Quest for Peace (1987), played a prison guard in Justice League (2017) and played Jerry, a Metropolis cop in Zack Snyder's Justice League (2021).
- No relation to "Out of This World" star Doug McClure, despite a popular misconception.
- He has appeared in three films that have been selected for the National Film Registry by the Library of Congress as being "culturally, historically or aesthetically" significant: Superman (1978), Back to the Future (1985) and Apollo 13 (1995).
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