Menotti studied art in Bologna, semiotics in Berlin and filmmaking in New York. He published the graphic novel Europa as well as many comics and illustrations in Il Manifesto, L'Espresso, Frigidaire, Comic Art, Blue. As a screenwriter he created the TV series
Zero (2021) for Netflix and
Vita da Carlo (2021) for Amazon Prime Video. He wrote a number of feature films, including
Blessed Madness (2018),
All You Need Is Crime (2019),
The Legend of the Christmas Witch 2: The Origins (2021), and
They Call Me Jeeg Robot (2015), nominated for best screenplay and winner of seven David di Donatello awards in 2016.