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- A scrappy, feisty, fiercely loyal Chicago family makes no apologies.
- A nine episode one-hour series that follows a group of real-life Los Angeles lesbians as they go about their daily lives, at work and play.
- Jackie is spending time with her family at the beach but still shows that she's in charge. At the hospital, Gloria is concerned with the growing disappearance of drugs and gets Jackie to give training to staff on how the properly use the dispensing system. Dr. Cooper lodges a formal complaint against her and she comes within inches of being shot when a deranged patient fires their gun at no one in particular. Eddie is still trying to contact her but she ignores him completely. Until he finds a way to get her attention that she simply cannot avoid.
- Jackie is still incensed at having found Eddie in her house and tells him to stay away; he's not very receptive to the idea. Zoey performs brilliantly when a young child is brought in unable to breathe. A patient with stage 3 lymphoma is brought to the hospital but Dr. Cooper doesn't react well to Jackie's suggested treatment. She decides to help him out anyways. Dr. O'Hara and self-confessed sex addict Sam take it to the next level.
- Everyone at the hospital is put out - especially Dr. O'Hara - when Dr. Cooper is listed in a monthly magazine as one of the 25 best doctors in Manhattan. Jackie is less than pleased when Kaitlin shows up on a play date at her house. She's even less pleased when Kaitlin sees her snorting a line. At the hospital, she's almost caught taking drugs out of the dispensary using Zoey's access number. Back at home, she's dumbfounded when she sees who husband Kevin's new friend is.
- After a disastrous family vacation, Jackie returns to work for a day of reckoning. The mounting pressures and conflicts in her personal and professional lives reach a boiling point. Unexpected alliances lead to revelations that even Jackie can't avoid. Between Dr. O'Hara, Eddie, Kevin and the drug dealer, the wagons are circling around Jackie Peyton.
- Post-birthday party, Fiona busts her lip open on her cast and Dr. O'Hara and Jackie stitch her up in the Peyton kitchen. Jackie notices Sarah Khouri's philandering behavior and brings up her concerns to Dr. O'Hara. Libby Sussman, the uber-patron of All Saints, is brought into the ER.
- After avoiding Eddie, O'Hara and the drug dealer who has come looking for his stolen pills, Jackie takes off early for a family vacation upstate. But when Jackie misplaces the stash of pills she brought to get her through the vacation, she starts to unravel bit by bit.
- Drunken father Frank is of no use to his dysfunctional family; Fiona meets a handsome stranger when her purse is stolen; Lip is shocked to discover his brother Ian is gay.
- Dr. O'Hara shows up at work still high on the Ecstasy she took the night before. Jackie deals with a young boy who may have a serious respiratory problem. His parents are thrilled when Jackie says they can do the necessary tests at All Saints but may have sent them home too early. Having recovered from his suicide attempt, Eddie visits Jackie's husband Kevin at the bar. Nurse Sam begins to ask if either Jackie or Dr. O'Hara have a drug problem. Dr. Cooper has taken to twittering and it's driving Jackie crazy.
- Jackie is mad a husband Kevin when he reveals that he went to the movies with Ginny Flynn and the kids during the children's play date. Jackie decides to sleep on the couch. At the hospital, Gloria Akalitus is still concerned about the seepage in the drug lockup and posts a security guard at the machine, which doesn't seem to do much good. Sam still pursues Dr. O'Hara, who saw it all as a one night stand. O'Hara also reveals to Jackie that she knows a famous international TV news correspondent. Akalitus asks Dr. Cooper if he will be the face of a new promotional campaign directed at patients who have the ability to pay.
- Jackie sleeps with Eddie at his apartment and tells him to stop seeing Kevin. Posters with Dr. Cooper's face are plastered all over the city, much to the disgust of Jackie and Dr. O'Hara. Jackie treats a female Iraq war vet with PTSD. Dr. O'Hara's ex, Sarah Khouri, comes to town and they're back on. With Eddie and the Pill-O-Matix becoming less reliable sources, Jackie finds ways to get pills. Eddie ignores Jackie's request and invites Kevin out. Jackie allows Fiona to have a fake cast on her arm for her birthday.
- Max is not happy with the revelation that she didn't tell him about her alter Buck re-emerging. She agrees to find a new analyst but the person she settles on lives in New York and their sessions will be by telephone. Marshall and Courtney meanwhile continue their sexual experimentation but with interesting results for both of them. Kate poses for some of Lynda's paintings and has a suggestion on how she could make money on the works. Charmaine and her fiancé have a big announcement. While in the house next door, Tara has memories of her childhood playing with Charmaine. As Max learns, she's up to something altogether different as well.
- Kate is less than thrilled with her mother's new friendship with Lynda. Kate accuses her mother of taking away all that's important to her. Kate is also starting to connect on the Internet in her Valhalla Hawkwind persona. She's not quite ready for what transpires. Charmaine is still trying to figure out a way to have Neil's baby but stick with Nick. She finally tells Nick what's going on and not surprisingly, he doesn't take it well. As for Tara, her alters haven't made an appearance for a while and gets ready for a neighborhood art show. Max's appraisal of her art doesn't go over well and they have a fight leading a fed up Max to pay a call on someone.
- Tara recalls another childhood memory of Mimi; at a bicentennial parade, a young Tara tells Charmaine that they can't go home. Tara confides to Charmaine about Max's infidelity, as well as her new memories of Mimi, realizing that she only experiences the memories while in the house next door. After being encouraged by Charmaine, Tara asks Beverly about the childhood memories; Beverly quickly changes the subject to Charmaine's wedding. Neil gives Charmaine the forms signing away his parental rights. Max holds an open house for his newly finished re-model of the house. During the open house, Alice emerges, scaring off potential clients. Kate and Zach begin dating. Marshall and Lionel go cruising at a local park. After forgiving Max for his infidelity, Tara transitions into Buck, who punches Max for sleeping with Pammy.
- Tara and Max's relationship is at a low ebb. After their fight at the art show, Max spent the night with waitress Pammy. It was supposed to be a one night stand with no strings attached but the next day she has a change of heart. Kate is growing a little weary of the kooks she's met on her website but is intrigued by one client who asks her out on a date. He turns out to be something of a surprise. Max and his friend have an interesting meeting with a school counselor. Charmaine tries to get Neal to sign away his parental rights to the baby now that she has Nick on side about the pregnancy.
- Eddie tells Jackie he can't keep lying to Kevin, whom he now considers a real friend. Akalitus announces that All Saints is vying for a visit from Michelle Obama and confides to Jackie that O'Hara is looking for work at another hospital. Coop tries to bury the hatchet with Sam. The rift between Jackie and O'Hara softens when Jackie tells her that she'll follow her to any hospital just to be near her. Kevin tells Jackie his buddy Eddie called and is out of a job and asks if she can put in a good word for him at All Saints.
- Much to Jackie's surprise, Kevin's younger sister, Tunie, shows up in the girls' bedroom, freshly hungover and tragically heartbroken after being dumped by her pilot boyfriend. On their way to work, Jackie tells Eddie she thinks Kevin installed Tunie to monitor her in the wake of his intervention. Lenny prepares Zoey a romantic picnic lunch only to crack her tooth when she bites into a sandwich where he's hidden his house key. Zoey talks things over with God, who's set up a makeshift piano bar in the ambulance bay. At the hospital, a Jewish Orthodox husband fights with his in-laws to have his critically injured wife moved to Beth Israel for a necessary operation. Later, bedlam ensues in the ER when two street meat vendors are brought in after a comically brutal turf war.
- Jackie's back in the swing of things, having re-hidden her stash of pills in the basement and mended fences with O'Hara. Zoey's working her first double and Jackie worries about her burning out. Lou, an out-of-work salesman, comes into the hospital and wins everyone over. O'Hara accepts the title of ER chief, which sparks a competitive streak in Coop. Kevin invites Eddie to a backyard barbecue to celebrate his new job. When Jackie gets home, she sees empty closets and drawers and panics-did Kevin leave her? She finds out he went to an Al-Anon meeting and the drawers are emptied because of a clothing drive at the school. Jackie asks Kevin to walk to the parish with her; she thinks they mistakenly gave away some sentimental items. She digs through the box of Grace's baby clothes to find what she was looking for-tiny mittens with bags of pills stashed inside.
- Jackie is on edge after realizing the stash of pills she stole from Bill the epileptic drug dealer is quickly dwindling. With a head of steam, Jackie confronts Eddie about his recent text exchanges with Kevin's younger sister, Tunie. Eddie maintains that it's completely innocent, while making the point that Jackie has no leg to stand on. Coop remains determined to battle O'Hara for the ER Chief title, but suffers a huge emotional blow when his mothers announce they're divorcing. Lou, the down-on-his-luck salesman, returns to the ER much worse for the wear. Akalitus enlists Jackie and Thor to help her ferry the Virgin Mary statue to Eddie's storage room, where it will be safe from repossession during the Catholic Church's impending de-consecration. Later, Jackie and O'Hara spar over whether to confront a belligerent mother who's making false claims about her daughter's need for treatment in order to stay on public assistance. At the end of a long, grueling day Jackie hits a new low when she makes her first illicit drug transaction with Bill.
- Tara starts her psychology classes in fine form as one of her alters, Shoshana the psychologist emerges. She's thoroughly embarrassed but her teacher, Dr. Harris seems quite relaxed about it all. Until his next class where his comments about DID upset her. Meanwhile, Max continues losing customers to a competitor who has a solution for him: sell out to them and take a full-time job with them. The deal doesn't include Neil however. Kate decides she wants to go to Japan as an English teacher. Marshall and Lionel are assigned to make a film together.
- 2009–201127mTV-MA7.9 (185)TV EpisodeMax gets his mother to sign off on selling the lawn care business. He hasn't seen her two years and is shocked by what he finds. Kate leaves on her trip to Japan but does so without saying goodbye to anyone, much to Tara's annoyance. Events in Japan conspire against her even getting out of the airport however. Tara is planning a baby shower but Charmaine doesn't think she's helping so Alice emerges and neatly organizes everything. When Tara and Charmaine go grocery shopping T emerges causing her usual havoc.
- Charmaine goes into labor but is angry at Tara who, under stress from an excess of school work and the pressure of upcoming exams, has various alters emerge. After the baby is born, Charmaine makes it clear she can't trust Tara and doesn't want her around her baby. Having renegotiated a new assignment in Japan, Katr has a last minute panic attack and doesn't get on her flight. She delays going home by hanging around the airport and a new revelation suggests another career choice. A bit of advice from a flight attendant opens her eyes. It also leads to a crisis of confidence in herself. Tara tries to get out of a scheduled test but Dr. Hattaras isn't very sympathetic. At a meeting with her alters, Tara lays down the law. The time and place for the meeting isn't quite appropriate.
- 2009–201126mTV-MA7.7 (207)TV EpisodeFascinated by Tara's alters, Dr, Hattaras proposes they work together on an academic paper. Tara just wants to drop his course but he won't let her. Max is finding that his new job a Orgaworld isn't quite what he had expected. Marshall doesn't think their film is good enough to submit to the film festival leading to a major disagreement with Noah. Kate starts her training as a flight attendant and seems to be getting on quite well. Charmaine and Neal meanwhile are emotionally and physically drained by their newborn daughter but the new mom steadfastly refuses Tara's offer of help.
- Whitney welcomes one-time flame Sara to town and the girls waste no time getting reacquainted, but their hot weekend together ends all too quickly and just as Whitney says goodbye to her, another former flame arrives in town indefinitely and did we mention flame number three, Romi? After a wild night out with friends, Rose dutifully returns home to Natalie, her girlfriend of seven months. Monogamy still doesn't come easy for this "reformed player" and the pressure her family dishes out to settle down doesn't help. For Nikki and Jill, wedding bells are already in the air - but wedding planning with two brides can be stressful! The ladies enlist the help of a wedding planner to produce their elegant affair but just as Nikki's nerves begin to subside, Jill's anxiety skyrockets when she sees the price tag attached to their dream nuptials. As producer of LA Fashion Weekend, Mikey is no stranger to stress. She's on a tight schedule and doesn't have time for ill-prepared models and lets their agency feel her wrath. Tracy is new to the lesbian scene and finally coming into her own, but her mother's don't ask, don't tell policy is difficult for her - especially since there's so much to talk about, like her new relationship with Stamie, which has its own complications.