Ronald Reagan's voice can be heard as a radio announcer, a job that Reagan held before he started as a film actor.
Producer Robert Lord favored Ronald Colman in the title role but was overruled by studio boss Jack L. Warner, who cast studio contractee Edward G. Robinson. After director Anatole Litvak was assigned to the project, Lord's role shifted from producer to associate producer.
Cary Grant was considered for the role of Dr Clitterhouse. At one point, Bette Davis was considered.