The title refers to the common exclamation "Suffering Catfish!" that dates backs to the 19th century to a similar expression "Suffering Moses!" Another variation on the expression was used by another cartoon feline, Sylvestor the Cat in the Warner Brothers cartoon shorts, "Suffering succotash!"
Nothing of any particular interest or originality happens in this short. Tom is having his usual fun tormenting Jerry but the mouse runs into a stray cat and pretends to be best friends with him (by kissing him-gay lovers?) to upset Tom. Soon both cats are feuding over Jerry whilst being set-up by him. Oh, do watch my sides as they just might split!
I wasn't really impressed and there's not a lot to laugh at in the 8-minute running time. The short actually has some dialogue in it but there's no credited voices for some reason on this page. There's nothing I can recommend about this cartoon as it is Tom and Jerry at their most basic. The title is rather generic too.