The series portraits real-life couple Sandra Mondaini and Raimondo Vianello who play themselves as show-people and screenwriter. In the series there are indeed often references to real events and people of the Italian showbiz, including former Italian prime minister Silvio Berlusconi as owner of the Mediaset television group which produced this and other shows featuring the couple. Starting from season 5 there are also several appearances of the Filipino family the couple adopted in real-life, playing themselves.
The episodes always end with Sandra and Raimondo in bed at the end of the day. Sandra always complains about being bored of her daily life with no interesting events, despite having regularly had a busy and adventurous day. Then she turns off the light in order to sleep, but then immediately begins shaking her legs under the sheets due to nervousness. In season 1 Sandra's complaints were part of a dialogue with Raimondo, while he was reading a book. Starting from season 2 the scene switched to a monologue of Sandra, with Raimondo reading the sports newspaper La Gazzetta dello Sport saying no word. Actor Raimondo Vianello was indeed a huge sports fan, former footballer and boxer. During the production of the show he was also the presenter of football show Pressing, aired on Italia 1 (also part of the Mediaset group producing Casa Vianello) after football matches of the Italian Serie A or UEFA Champions League. He also owned and played for a football team called SAMO, which appears in several episodes.
The series is almost entirely set in Vianello's apartment, with only a few exceptions of external settings or other interiors.
Actresss Giorgia Trasselli played the maid Tata in all episodes starting from the third of season 1. In an interview she stated that she was initially cast for the role of a neighbor.
Sandra and Raimondo are supposed to own a dog named Zorro as stated in several dialogues. The dog is only briefly shown in the intro of seasons 2, 3 and 4, but never appears in the episodes.