Lacey Chabert is the first actress to play Tanya for more than one instalment of the An American Tail films. The first 2 films each had different actresses.
This marks the final film of the "An American Tail" franchise. Due to the negative impact it received from An American Tail: The Treasure of Manhattan Island (1998),
Universal Studios made a decision of ceasing production to the franchise.
The staff of Universal Studios made a decision of doing away with the characters and elements from An American Tail: The Treasure of Manhattan Island (1998) in this movie because of perceived racist stereotyping regarding the Lenape mice and the stereotypical white supremacists regarding the villains as the Cheese Factory owners are arrested off with their names confidential. They are all replaced with new characters.
Following the strict changes for this movie, background settings were redone, including the wall of the Mousekewitz's home, such as one of the pictures, like the large mouse swimming towards a woman (showing only her bare shoulders, implying she's nude) as shown in An American Tail: The Treasure of Manhattan Island (1998), is removed from the wall due to being referenced to bestiality, if not detected and censored out from the previous movie.
Bridget was still grounded from appearing in this film not only due to her actress' illness of cancer, but also due to the racist act including the "red skin" blushing technique given to Tony Toponi in An American Tail: The Treasure of Manhattan Island (1998) while then-child actor Thomas Dekker was present. Tony's appearance became strictly professional, meaning he's grounded from falling for anyone else.