When Dr. Romano signs to Reese, he is saying "Take care of your father."
Hallee Hirsh takes over the role of Rachel Greene. A clip in the "previously on E.R." opener from a previous episode, 6.21 "Such Sweet Sorrow," has been edited to replace the old actress with the new.
In this episode it is revealed that Dr. Malucci is a father.
"Blood, Sugar, Sex, Magic" is also a title of an album by the Red Hot Chili Peppers. Carter listens to the titular song on headphones at his grandmother's house.
When Mark said that Dr. Dave wasn't the first to get caught doing an 'unauthorized physical', he was referring to himself. Season 1, episode 3, Mark and his then-wife Jennifer were caught 'celebrating' in one of the bathrooms.