When Carlton is in the hospital, he tells the nurse "I've got a reputation to uphold. What if I decide to run for political office?" She replies that she'll tell him the same thing she told the last person who asked that, "Just say you didn't inhale." This is in reference to President Bill Clinton giving the "I didn't inhale" response to accusations during his presidential campaign that when he was in college he smoked marijuana.
The title is a reference to Just Say No which was an anti-drug campaign in the 1980s and the 1990s