None of the actresses were thrilled with this script as it involved the girls raising minks for profit, however they did the show anyway. All of the actresses in real life were animal activists.
Blanche states she's age 55. Rue was only 52 when this episode aired.
The building shown from the window in Dr. Barnsfeld's office is actually part of the TRW (now known as Northrop Grumman) Space Park in Redondo Beach, CA.
This is the episode for which Rue McClanahan won the Emmys for Outstanding Lead Actress in a Comedy Series at the 39th Primetime Emmy Awards (1987).
Philip Sterling, who plays psychiatrist Dr. Barensfeld, and Vince Cannon, who plays veterinarian Dr. Parks, both die within four months of each other in 1998: Sterling from myelofibrosis, a bone marrow disease, and Cannon from lung cancer.