The owner of the hotel in Florence where the Ricardo/Mertz party stays is named Sig. Nicoletti. The choice of this name probably came from Louis Nicoletti, a frequent face in episodes of this series, and an Assistant Director on Lucy's later sitcoms, as well as Lucy's film with Henry Fonda, Yours, Mine and Ours (1968).
Final appearance of Joseph A. Mayer and Michael Mayer as Little Ricky. In season 6 he will be portrayed by Richard Keith.