This episode appears to be partially based on the 2003 Murder of Gregory Glenn Biggs. On October 26, 2001, 25-year-old nursing assistant Chante Jawan Mallard struck 37-year-old Gregory Glenn Biggs, a homeless man, with her automobile, in Fort Worth, Texas, U.S. The force of the crash lodged Biggs into the windshield. Mallard then drove home and left the man lodged in the windshield of her car, parked in her garage. He died a day or two later. Mallard was convicted and sentenced to 50 years imprisonment for her role in his death. The CSI: Crime Scene Investigation (2000) episode Anatomy of a Lye (2002) is also based on the same case.
Dylan Baker has portrayed three different characters throughout the series:
- Episode 2.11 His Hour Upon the Stage (1991) - Sean Hyland.
- Episode 9.4 Flight (1998) - Aaron Downing.
- Episode 14.11 Darwinian (2004) - Sanford Rems.
- Episode 15.10 Enemy (2004) - Sanford Rems.
- Episode 16.20 Kingmaker (2006) - Sanford Rems.
Kate Burton plays Erica Gardner in this episode and three others, but she previously played the role of Sister Bettina in episode 2.17, Sisters of Mercy (1992).
John C. Vennema played three different characters over the course of the series:
- Episode 14.11 Darwinian (2004) - Dr. Aaron Geller
- Episode 5.16 Wannabe (1995) - Dr. Stephen Prescott
- Episode 3.5 Wedded Bliss (1992) - Victor Shay