This episode is the first to provide any details whatsoever about Nog's mother, Prinadora. Indeed, it is the only episode to do so. She would be mentioned again in "Ferengi Love Songs", but no new information would be presented.
This episode is the last time that we see the holo-communicator being used until either Shinzon or the USS Enterprise-E's versions of it in Star Trek Nemesis.
The title is a parody on the expression "Dr. Livingstone, I presume," which the reporter Henry Morton Stanley used when he found the lost physician David Livingstone in the town of Ujiji on the shores of Lake Tanganyika on November 10, 1871. Coincidentally, this episode was directed by series regular director David Livingston.
Dr. Lewis Zimmerman was named for Herman Zimmerman, a production designer for Star Trek: The Next Generation (1987), DS9, and the four TNG movies.
This is the first appearance of Dr. Lewis Zimmerman (the creator of the Emergency Medical Hologram) as a real person on any Star Trek series, having previously appeared only as a hologram on the Voyager episodes "Projections" and "The Swarm". He appeared as a real person again in Voyager: "Life Line".