- House cares for a young Katrina victim, the alleged daughter of an old friend of his. He supposes she has hallucinations because of the heart, but it turns out not to be the cause. House discovers a disease that her grandfather had.
- A Katrina survivor, presumably the granddaughter of a famous blues singer, convinces House's friend Dylan Crandall that he is her father. When the girl is brought in with a deadly illness, House is sure the girl is faking, but Crandall wants her as his daughter and Crandall won't agree to a paternity test. As House and team try to save the girl's life, House and his conscience fight over the truth vs. his friend's real desire to take the girl in.—mama.sylvia
- House's ex-band mate brings in a 16-year-old Hurricane Katrina victim suffering from hallucinations and making surprising claims about the identity of her father. House believes the child to be a scam artist since both her mother and grandfather were drug addicts. Meanwhile Cuddy is still on the hunt for a sperm donor and has recruited House to sift through the candidates to find an ideal match.
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