In the final showdown between Steve and Barry, involving the spiked drinks, Barry mentions that he knows that Steve has seen The Princess Bride (1987), as if he will use that information to figure out which glass has been drugged. Given that Steve's plan of drugging both glasses is identical to Westley's from the film, Barry can't have used the information very well.
Newspaper Headline gag: " American Dad " Releases DVD, Small Girl From Basement
The title is a play on the phrase, "With friends like these". The full phrase is "With friends like these, who needs enemies?".
At one point, when the camera pans back from Francine in a series of pictures, the final shot is an aerial view of Langley showing 3 treble staffs of six measures among the streets (possibly the music for the American Dad theme).
When Stan passes through the X-ray scanner at the CIA building, he mentions Oingo Boingo, a New Wave/Ska band fronted by Danny Elfman.