This episode was re-dubbed with Dave Coulier and Kath Soucie as it was meant for the syndicated, but was switched with the ABC year 2 shows. The original surfaced in the UK versions of the show with Lorenzo Music and Laura Summer as the voices of Peter and Janine. Later in America it re-aired on USA and Fox Family with Music and Summer. The re-dubbed version with Dave and Kath was not included on the DVD. As of 2017, can be viewed in full on Netflix in the United States.
The episode was switched in airings with "Transylvanian Homesick Blues" because "Slimer, Is That You?" was a noted J. Michael Straczynski-written episode in order to bring some of his scripts to season three.
The voice actors were recorded on January 7 and 9, 1987. Arsenio Hall and Maurice LaMarche recorded on January 9, 1987. For the alternate version, Dave Coulier and Kath Soucie recorded their lines on September 24, 1987.
After Egon awakens in Slimer's body, he recites the third law of Newton's Laws of Motion, "For every action there is an equal and opposite reaction."
Egon tells Peter they must first know the enemy. This is a tenant from the "Art of War" by Sun Tzu, "It is said that if you know your enemies and know yourself, you will not be imperiled in a hundred battles..."