The title is a variation of a quote from William Shakespeare's 'Romeo and Juliet': "What's in a name? that which we call a rose, By any other name would smell as sweet."
The book that the Professor asks for during the surgery on Gilligan's nose is "Medicine Made Easy."
This was the last black and white episode of this series.
As the Professor is about to begin operating, patient Gilligan says, "Maybe I'd feel better if you were like Dr. Ben Casey (1961)," and promptly rips open the right side of the Professor's smock, making it resemble what is still sometimes referred to as a "Ben Casey Shirt."
The final time that Russell Johnson and Dawn Wells aren't included in the opening credits and the final time with the lyrics "and the rest. " Starting with the next episode and the rest of the series, they are in the opening. It turns into color, and the words are "The Professor and Mary Ann."