This is the first time Jack interacts with his great aunt, Amara.
Amara reminds Dean of how she told him that they would always help each other the first time that Dean and Amara met in Out of the Darkness, Into the Fire (2015).
Dean tells Sam that Jack isn't family, isn't like Sam or Cass. This is likely to help Dean separate himself from his feelings for Jack who is destined to die to save the world. Dean had previously called Jack his kid.
Some of the episode's format is similar to the episode Stuck in the Middle (With You) (2017), with the captions showing when a part of the episode focuses on a specific character.
In the opening scene Amara is reading Norwegian Wood, written by Haruki Murakami.