Jared Padalecki said that during day of the filming of the scenes in the Chinese restaurant he was suffering very badly from food poisoning. Most of what we see on screen was filmed by Jensen alone, with Jared coming in and doing all of his coverage at the end of the day.
Ryan Grantham, who plays Todd the bullied boy who gets super strength, is convicted for the March 2020 murder of his mother and sentenced to life in prison. source: Variety 09/23/22.
When talking to Wes, Dean says that they're also "FBI, and on Thursdays we're Teddy Bear Doctors". This refers to the fact that the show aired on Thursday night during season 4.
Dean says to the little boy, "with great power comes great responsibility", this is a line from Spider-Man (2002) which actor Ted Raimi appears in & is directed by his brother Sam Raimi.
The Health Inspector badge that Sam flashes says his name is Adrian Diepold. Adrian Diepold was a second assistant director on the show for 30 episodes.