This is the first instance of a situation where somebody who has their Pineal gland removed exhibits ultra-sensory abilities. The Pineal gland is extremely small( like a grain of rice) and sits where the base of your head meets the neck, between the two halves of your brain.
This chapter is a total homage to movie "Ghostbusters". The action takes place at Reitman University, located on Ray Parker jr. Avenue, the Middle Man HQ is seen to be located in a brick firehouse, references an " Egon Spengler Award", and even Louis' description of the ghost, "I don't know if it had legs or not, but I know it had arms because it reached out for me!" Is directly out of the movie.
Upon seeing the Matrix-esque physics lab, Wendy says "Holy Wachowski Brothers". When this episode was made Lana (formerly Laurence) Wachowski had been openly living as a woman for several years and Lana and Andy had taken to calling themselves 'the Wachowskis'.
WILHELM SCREAM: When Wendy kicks the Middleman in the crotch.
There is a Star Wars homage in the 'wretched hive of scum and villainy' line used by Dub-Dub.