The comic book series Bitch Planet includes an event titled "Duemila" or "Megaton"; in issue #4 the event is described: "Megaton is one of many modern descendants of Calcio Fiorentino, a 16th century Italian sport... Teams may have any number of players, but their combined weight can be no more than 2,000 lb
In the 2017 film Lost In Florence, Brett Dalton plays a former college football star who travels to Italy and becomes involved in playing Calcio Fiorentino.
In the sixth episode from the second season of Syfy Channel's HAPPY! (titled "Pervapalooza"), the demon Orcus references Calcio Storico while trapped inside Blue Scaramucci's body.