The girl that Jeff says "Hey, gorgeous" to, in the Medical Lab, is reading an STD pamphlet.
At the beginning after Jeff sits down, Abed is talking to a very pregnant woman in the background. This is the same student who threw aside a faulty condom at the STD Fair (S01E11) after the dean told Abed to make an announcement instructing everyone not to use the faulty condoms if they have sex, as Abed reacts in surprise, the pregnant student starts crying. Later Abed can be seen (again in the background), with the pregnant student, talking to the male student who (likely) impregnated her at the STD Fair. He appears to react angrily and shoves Abed repeatedly, before Abed runs off. Throughout the episode, Abed can be seen with the (now) reconciled couple, and delivering the baby in the back of a car towards the end of the episode. This storyline is never directly addressed, instead providing (literal) background context for Abed's basic midwifery knowledge at the end of the season.
In the car to get ice cream, Pierce says he is going to put some Loggins in the CD player. Chevy Chase was in "Caddyshack" (1980) which featured a hit song by Kenny Loggins.
The DVD commentary mentions that the episode writer Hilary Winston is the woman sitting in the health center next to the woman Jeff keeps pointing to.
Television critic Alan Sepinwall appears as a Greendale student alongside Eric and Mark Millot.