The pilot was produced for Nickelodeon. The Modifyers co-creator, Chris Reccardi, has stated it was rejected in favor of producing Back to the Barnyard and that Nickelodeon was not interested in show with female lead at the time.
The pilot gained a good amount of popularity due to Zone's pornographic parody made in 2013.
The pilot first aired in 2007 on Nicktoons Network as part of Shorts in a Bunch.
Cartoon Network picked up the pilot after Nickelodeon rejected it, but dropped it after only airing the first half.
On May 2, 2019, Chris Reccardi died at the age of 54 after suffering a heart attack while surfing in Ventura, California.