The Orb of Thesulah, which is a plot device in this episode, was also a major plot device in both the Buffy the Vampire Slayer (1997) and Angel (1999) TV shows.
The psychic at Good Graces tells Dean he's "a virile manifestation of the divine." Dean is Michael's sword and in Hebrew Michael means one who is like God.
Good graces restaurant was a reused set from an earlier episode, Lucky Chins Restaurant in Wishful Thinking (S04E08)
During the seance in the first scene the woman asks if the dog Sadie is with her uncle Danny. Jared Padalecki has a dog named Sadie.
Second episode to not feature the Impala.