A college graduate with a once-promising career, Justin has eaten his life away to the point of never leaving the house for anything but food. Now only the help of Dr. Now's weight-loss program can restore his hopes of living a happy, productive life.
Lacey's weight, caused by overeating, keeps her housebound but doesn't deter her love for Ricky. However, Ricky's sister Sharon adds complexity to their relationship.
In the 4th year of his weight loss journey, Sean struggles to get past the loss of his mother and live on his own. Dr. Now intervenes to control Sean's eating for a time, but if Sean can't learn to control himself, he will face the direst of consequences.
Nothing means more to Chris than his relationship with his daughter, Zoey, but now he feels he is failing her as his weight gain begins to limit his mobility. Chris turns to his mother, whom he hasn't seen in seven years, to help get his life on track.
Growing up in foster care, David suffered from a lack of attention and didn't develop a sense of self-worth. Now he weighs 800 pounds, and he's relying on his foster mum to support him as he finds the motivation to change and save his own life.
With the Perrios struggling with different stages of their weight loss journey, the revelation of a past tragedy explains their resistance to recovery. The siblings must now come together to overcome their fears and forge a path towards a healthy future.
With the support of his fiance, Kathryn, Robert turns to Dr. Nowzaradan in a final, desperate attempt to save his life. He tries to reverse a lifelong food addiction that has left him bed-bound, saddled with grotesque lymphedema, and nearly 900-lbs.
Fearing he'll suffer the same fate as 700-pound brother David, Benji hopes to be able to support both himself and his brother on their life-or-death weight loss journey.
Twins Kandi & Brandi have a combined weight totaling over 1100lbs. These inseparable twins fear losing each other to obesity, so they make a change together. But a life-threatening event during weight loss surgery recovery may separate them forever.
Battling severe depression in the wake of a suicide attempt, 46-year old Olivia hasn't left her Chicago basement in two years. With one last chance at a new life, Olivia will travel to Houston with the hope of having a life-changing surgery.