The person who recommended splitting up the movie into two volumes to Lloyd Kaufman was Quentin Tarantino. Lloyd liked the idea. It made sense because there was a huge amount of footage and the movie would be over 3 hours long if it wasn't split up into two parts.
There was a special secret screening of the film at the Cannes Film Festival in France on May 16, 2013.
The first public screening of the film took place at Troma's own Tromadance Film Festival in Asbury Park, New Jersey at Asbury Lanes on Saturday, April 13, 2013. The fest and film were free to to the public.
At the time this movie entered into pre-production, another Troma Nuke 'Em High movie was in development in Spain (Class of Nuke 'Em High Part IV). The Spanish project was canceled to not enter in conflict with Return to Nuke 'Em High Volume 1 (2013) and the Spanish company went on to produce another sequel for another underground saga, Ted V. Mikels' The Corpse Grinders 3 (2012).
The majority of the film was filmed in the closed down Niagara Falls High School in Niagara Falls, NY. The steps on the grand staircase in front of the school were broken down and the actors had to watch their steps while they acted on the steps to stay away from injuries.