The character, Dr. Charlie Harris ( Michael Shanks ), makes a joke about werewolves and vampires being quite popular and overused now. Daniel Gillies (Dr. Joel Goran in the show) starred in the famous CW vampire/werewolf show, The Originals (2013), while he starred in Saving Hope. He actually chose to continue as a main character in The Originals, instead of continuing in Saving Hope.
The tale of a medical student being assigned to dissect a cadaver who turns out to be a recently deceased close relative (Maggie and her father) is a very old medical school urban legend.
Kristopher Turner (Dr Gavin Murphy) and Dayle McLeod (Lily the prisoner) previously worked together on the show The LA Complex where they played a couple.