The character Colt Palomino is played by Keith Carradine, who is the father of Martha Plimpton, who plays Virginia Chance on the show.
Keith Caradine, playing Colt Palomino, mentions several times that he was on one episode of Bonanza. He appeared as the character Ernette for one episode in 1971, although he was 23 at the time, not 9 like he told Burt.
Keith Carradine played Wild Bill Hickock and Garret Dillahunt played Jack McCall the man who shot Wild Bill on the TV series Deadwood.
When Frank yells' "Everyone's gonna get laid" the man that leans out from the aisle is series consulting producer and episode director, Tim Stack.