In the comics, Gypsy and Vibe were both members of the Detroit-era Justice League (along with Steel and Vixen).
During their trial by combat, Cisco and Gypsy briefly travel to Earth-38, Kara's Earth from Supergirl (2015).
Art 22:23 Iris tells her dad she wants to buy a pet to expand her and Barry's household. This ignores the pet turtle McSnurtle which H. R. gave them at their housewarming party.