Lucien says that nobody cares about people "past the 18 to 49 demographic". The show was dropped from A&E despite strong ratings because it did not do well with 18 to 49 year old viewers.
Tucker Bagget makes a reference to the legendary Buck Owens, a country/western musician, in his opening statement.
Radha Mitchell (Alex Graham) and Graham Greene (Malachi Strand) we're both in the movie The Shack (2017).
Radha Mitchell (Alex Graham) is an Australian actress, and Robert Taylor (Walt Longmire) is also Australian. They worked together previously in the movie Rogue (2007).
Patch Darragh (Dave Milgram), Tom Wopat (Sheriff Wilkins), and Mike Pniewski (Judge Drood) have all made guest appearances on Madam Secretary.