There is a short cameo by Beck about two and a half minutes in (2:25) as a man in a white suit presenting Jack with a "box with something in it".
The music video for "The Hardest Button to Button" is the third White Stripes video directed by Michel Gondry.
The cover of the single is an allusion to the graphics of Saul Bass, seen in the movie posters and title sequences of films such as Anatomy of a Murder and The Man with the Golden Arm.
The cover also alludes to Jack White's then-broken index finger and his obsession with the number 3.
Jack White says that the song is about a child trying to find his place in a dysfunctional family when a new baby comes.