Marcy gets the idea for her memory recovery procedure from the conversation with MacLaren at the waterside in the episode 207 entitled "17 Minutes". He tells her when I was near death "my own consciousness took refuge in the memories of Grant MacLaren."
The season 4 episode of Supernatural, "Family Remains" uses the same country house featured in this episode.
The house used for the standoff is the same one used in the X-Files episodes "Home" and "Aubrey".