As of the premiere of this episode, Samantha Morton, who plays Alpha, is the second Oscar nominated actor to appear on the show. Keisha Castle-Hughes was the first but only made one appearance in the episode Slabtown (2014).
The small clearing where Negan throws up appears to be the same clearing where he killed Glenn and Abraham.
Dan Fogler and Samantha Morton previously appeared together on Fantastic Beasts and Where to Find Them (2016).
Samantha Morton really shaved her head to play the role of Alpha.