"Familiar Wife" has Ji Sung and Han Ji-min playing lead roles together for the first time. They did previously appear in 2003 SBS drama series "All In" with Ji Sung playing a second lead male role and Han Ji-min playing the teen version of the lead female character.
First script reading took place May 9, 2018 at Studio Dragon in Sangamdong, Seoul, South Korea.
"Familiar Wife" takes over the tvN Wed. & Thu. 21:30 time slot previously occupied by "What's Wrong With Secretary Kim" and followed by "Hundred Million Stars From the Sky" September, 2018.