According to the head writer Robert Hewitt Wolfe, Odker, the search engine mentioned in the show, stands for ODin K [E] Reichenbach, the company founder of said search engine and company.
Unfriended, the episode title, is a term borrowed from Facebook.com, the social media site and company, where a "friendship status" is revoked, as in the person unfriended will not have access to the full features of the other's "web page".
Jodi Long who appeared in this episode as Mrs. Tseng also appeared with star Jonny Lee Miller on six episodes of 'Eli Stone' in which Miller played the titular lead character.