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- Using a crack team of doctors and his wits, an antisocial maverick doctor specializing in diagnostic medicine does whatever it takes to solve puzzling cases that come his way.
- Shaun Murphy, a young surgeon with autism and Savant syndrome, is recruited into the surgical unit of a prestigious hospital.
- The series follows Adrian Monk, a brilliant former San Francisco detective, who now consults the police as a private consultant whilst battling with an obsessive-compulsive disorder.
- Follows the personal and professional lives of six twenty to thirty year-old friends living in the Manhattan borough of New York City.
- F.B.I. Special Agent Seeley Booth teams up with the Jeffersonian's top anthropologist, Dr. Temperance Brennan, to investigate cases where all that's left of the victims are their bones.
- Professional writer and amateur sleuth Jessica Fletcher uses her intellect, charm, and persistence to get to the bottom of every crime she encounters.
- A young woman with a troubled past is drawn to a small town in Maine where fairy tales are to be believed.
- Los Angeles homicide detective Lieutenant Columbo uses his humble ways and ingenuous demeanor to winkle out even the most well-concealed of crimes.
- Three parapsychologists forced out of their university funding set up shop as a unique ghost removal service in New York City, attracting frightened yet skeptical customers.
- Four friends band together against an anonymous foe who threatens to reveal their darkest secrets, while also investigating the disappearance of their best friend.
- The misadventures of a talking sea sponge who works at a fast food restaurant, attends a boating school, and lives in an underwater pineapple.
- An unfairly discredited but brilliant ER doctor winds up working with his younger brother in the Hamptons as a concierge doctor to the uber-rich and ultra-elite.
- A group of ambitious misfits try to escape the harsh realities of high school by joining a glee club headed by a passionate Spanish teacher.
- A new medical director breaks the rules to heal the system at America's oldest public hospital.
- A 12-year-old boy and his best friend, a wise 28-year-old dog with magical powers, go on a series of surreal adventures in a remote future.
- A former White House Communications Director starts her own crisis management firm only to realize her clients are not the only ones with secrets.
- Using high tech gadgets, two kids have to save their reactivated OSS top spy parents when they're taken by an evil, high tech enemy.
- The daily trials and tribulations of Tim "The Tool Man" Taylor, a television show host raising three mischievous boys with help from his loyal co-host, loving wife, and eccentric neighbor.
- When two kids find and play a magical board game, they release a man trapped in it for decades - and a host of dangers that can only be stopped by finishing the game.
- Goaded by his buddies, a nerdy guy who's never "done the deed" only finds the pressure mounting when he meets a single mother.
- Detective Jane Rizzoli and Chief Medical Examiner Dr. Maura Isles team up to solve crimes in Boston.
- Twin siblings Dipper and Mabel Pines spend the summer at their great-uncle's tourist trap in the enigmatic Gravity Falls, Oregon.
- Boston Legal is a spin-off of the long-running David E. Kelley series The Practice (1997), following the exploits of former Practice character Alan Shore (James Spader) at the legal firm of Crane, Poole, and Schmidt.
- The Wild West adventures of Ben Cartwright and his sons as they run and defend their Nevada ranch while helping the surrounding community.
- The cases of an easy-going ex-convict turned private investigator.