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- CreatorAmy Sherman-PalladinoStarsLauren GrahamAlexis BledelKeiko AgenaA dramedy centering around the relationship between a thirtysomething single mother and her teen daughter living in Stars Hollow, Connecticut.
- CreatorChuck LorreBill PradyStarsJohnny GaleckiJim ParsonsKaley CuocoA woman who moves into an apartment across the hall from two brilliant but socially awkward physicists shows them how little they know about life outside of the laboratory.
- CreatorDavid CraneMarta KauffmanStarsJennifer AnistonCourteney CoxLisa KudrowFollows the personal and professional lives of six twenty to thirty year-old friends living in the Manhattan borough of New York City.
- CreatorDan SchneiderStarsDrake BellJosh PeckMiranda CosgroveTwo teenage boys with clashing personalities - one is a slick musician, the other a clumsy nerd - must navigate high school and family life together after becoming step-brothers.
- CreatorPaul T. ScheuringStarsDominic PurcellWentworth MillerAmaury NolascoA structural engineer installs himself in a prison he helped design, in order to save his falsely accused brother from a death sentence by breaking themselves out from the inside.
- CreatorCarter BaysCraig ThomasStarsJosh RadnorJason SegelCobie SmuldersA father recounts to his children - through a series of flashbacks - the journey he and his four best friends took leading up to him meeting their mother.
- CreatorFelix HerngrenJacob Seth FranssonUlf KvenslerStarsFelix HerngrenJohan RheborgJosephine BornebuschThe lives of two very different families in the posh neighborhood of Solsidan in Sweden.
- CreatorElizabeth MeriwetherStarsZooey DeschanelJake JohnsonMax GreenfieldAfter a bad break-up, Jess, an offbeat young woman, moves into an apartment loft with three single men. Although they find her behavior very unusual, the men support her - most of the time.
- CreatorWhitney CummingsMichael Patrick KingStarsKat DenningsBeth BehrsGarrett MorrisTwo young women waitressing at a greasy spoon diner strike up an unlikely friendship in the hopes of launching a successful business - if only they can raise the cash.
- CreatorSteven LevitanChristopher LloydStarsEd O'NeillSofía VergaraJulie BowenThree different, but related, families face trials and tribulations in their own uniquely comedic ways.
- CreatorLeila GersteinStarsRachel BilsonJaime KingCress WilliamsNew Yorker and new doctor Zoe Hart accepts an offer from a stranger, Dr. Harley Wilkes, to work in his medical practice in Bluebell, Alabama. She arrives to find that he has died and left half the practice to her in his will.
- CreatorJason KatimsStarsPeter KrauseLauren GrahamDax ShepardThe lives and tragedies of the Braverman family tree.
- CreatorLee AronsohnChuck LorreStarsJon CryerAshton KutcherAngus T. JonesA hedonistic jingle writer's free-wheeling life comes to an abrupt halt when his brother and 10-year-old nephew move into his beach-front house.
- CreatorGreg DanielsRicky GervaisStephen MerchantStarsSteve CarellJenna FischerJohn KrasinskiA mockumentary on a group of typical office workers, where the workday consists of ego clashes, inappropriate behavior, tedium and romance.
- CreatorJosh SchwartzStarsMischa BartonAdam BrodyPeter GallagherA troubled youth becomes embroiled in the lives of a close-knit group of people in the wealthy, upper-class neighborhood of Newport Beach, Orange County, California.
- CreatorGreg DanielsMichael SchurStarsAmy PoehlerJim O'HeirNick OffermanThe absurd antics of an Indiana town's public officials as they pursue sundry projects to make their city a better place.
- CreatorDavid CaspeStarsEliza CoupeElisha CuthbertZachary KnightonThis Chicago-set sitcom follows the intertwined lives of six young urbanites trying to learn the ropes of adulthood. Through breakups and whatever other curve-balls life throws them, the pals stick together.
- CreatorDan HarmonStarsJoel McHaleDanny PudiDonald GloverA suspended lawyer is forced to enroll in a community college with an eccentric staff and student body.
- CreatorTina FeyStarsTina FeyAlec BaldwinTracy MorganLiz Lemon, head writer of the sketch-comedy show "TGS with Tracy Jordan", must deal with an arrogant new boss and a crazy new star while trying to run a successful television show without losing her mind.
- CreatorDan BerendsenStarsJean-Luc BilodeauDerek ThelerMelissa PetermanA 20-something bachelor bartender becomes an unlikely parent when an ex-girlfriend leaves a baby girl on his doorstep.
- CreatorStephanie SavageJosh SchwartzStarsBlake LivelyLeighton MeesterPenn BadgleyPrivileged teens living on the Upper East Side of New York can hide no secret from the ruthless blogger who is always watching.
- CreatorKevin BiegelBill LawrenceStarsCourteney CoxChrista MillerBusy PhilippsFollows the escapades and relationships of a group of neighbors living in Gulfhaven, Florida.
- CreatorLizzy WeissStarsKatie LeclercVanessa MaranoConstance MarieTwo teenage girls' lives are turned upside down when they find out they were switched at birth.
- CreatorJohn AltschulerMike JudgeDave KrinskyStarsThomas MiddleditchT.J. MillerJosh BrenerFollows the struggle of Richard Hendricks, a Silicon Valley engineer trying to build his own company called Pied Piper.
- CreatorMark BrazillBonnie TurnerTerry TurnerStarsTopher GraceLaura PreponMila KunisA comedy revolving around a group of teenage friends, their mishaps, and their coming of age, set in 1970s Wisconsin.