- Favorite movie is "La haine" by Mathieu Kassovitz.
- Frequently collaborates with Margherita Buy, co-starring in four films with her through 2013, Facciamo paradiso (1995), The Ignorant Fairies (2001), Saturn in Opposition (2007), and A Five Star Life (2013).
- Became very popular after an ice-cream commercial in Italy in which he was speaking "Italo-English".
- Was Giovanna Mezzogiorno's boyfriend until 2001.
- Graduated on a scholarship from the Theatrical School of Bologna under the direction Alessandra Galante Garrone. (1993)
- Attended the Intensive Seminar on Theatrical Movement and Introduction to bio-mechanics in a Drama course conducted by Nikolaij Karpov. (1997)
- Engaged to Laetitia Casta
- 2001: Named as one of European films' Shooting Stars by European Film Promotion.
- Favorite actor is Charles Vanel.
- He and Laetitia welcomed their second baby, a daughter, Athena, born 29 August 2009.
- First child with Laetitia Casta, Orlando, born on September 21st 2006.
- Member of the jury at the Venice Film Festival in 2003.
- Stefano and Bianca became the parents of a boy named Lorenzo (b. April 21, 2017).
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