The Taino people of Hispaniola encounter Christopher Columbus. Years later, a Spanish expedition led by Hernando De Soto lands in the American southwest.
The English arrive in North America. They have a disastrous encounter with the Inuit, build a settlement and name it Jamestown and try to survive their first winter. Warfare ensues between them and the native peoples of Massachusetts.
Native resistance in the east coast continues against the United States. Finally, President Andrew Jackson signs the Indian Removal Act and banishes the natives into reservations.