Originally shot for television.
Jessica Lange said in an interview "I let myself get talked into 'Losing Isaiah' because I hadn't worked for awhile. I knew it wasn't right, the script wasn't right, there was no ending. It just didn't feel right, and it never got right. It was a really difficult, and painful experience."
In between takes, a make-up girl accidentally scratched Halle Berry's corneas while applying eye drops, resulting in lots of pain, and missed work for Halle.
The film cast includes three Oscar winners: Jessica Lange, Halle Berry, Cuba Gooding Jr. and two Oscar nominees: David Strathairn and Samuel L. Jackson.